Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670445 | 0.88 | GRM5 (0.39) | GRM5SMN1; SMN2ATRSIRT2 | |
| SCHEMBL19365710 | 0.88 | CNR2 (0.52) | GRM5CNR2ALDH1A1ATR | |
| SCHEMBL19670601 | 0.86 | POLB (0.41) | CNR2ALDH1A1KMT2A | |
| SCHEMBL19365419 | 0.85 | EGFR (0.42) | GRM5CNR2SIRT2 | |
| SCHEMBL19364891 | 0.85 | MCHR1 (0.42) | GRM5CNR2ALDH1A1ATR | |
| SCHEMBL19365705 | 0.85 | MAP4K4 (0.38) | ALDH1A1KMT2AHDAC8SMN1; SMN2 | |
| SCHEMBL21841343 | 0.85 | KMO (0.41) | CNR2ALDH1A1KMT2A | |
| SCHEMBL19365441 | 0.85 | ATR (0.48) | TSHRNPSR1KMT2ASMN1; SMN2ATR | |
| SCHEMBL19364815 | 0.83 | GRM5 (0.46) | GRM5LCKATR | |
| SCHEMBL19365323 | 0.83 | GRM5 (0.41) | GRM5ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |