Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 9/20 | 0.35 |
| ▸ | CNR1 | P21554 | 4/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670550 | 0.89 | RHOA (0.39) | BRAFRHOACNR2CNR1GRM5 | |
| SCHEMBL19670658 | 0.89 | KDM1A (0.38) | BRAFRHOAPIM1PIM2KDM1A | |
| SCHEMBL19706147 | 0.88 | BRAF (0.44) | BRAFRHOACNR2CNR1KDM1A | |
| SCHEMBL19365566 | 0.85 | RHOA (0.36) | BRAFRHOAHTR1APIM1KDM1A | |
| SCHEMBL19706131 | 0.82 | POLB (0.42) | BRAFCNR2KDM1AMAOBGRM5 | |
| SCHEMBL17618837 | 0.81 | BRAF (0.36) | BRAFRHOAHTR1ACNR2CNR1 | |
| SCHEMBL19670657 | 0.80 | MPL (0.42) | CNR2KDM1AMAOBGRM5 | |
| SCHEMBL19706246 | 0.80 | BRAF (0.37) | BRAFCNR2KDM1AMAOBGRM5 | |
| SCHEMBL19706127 | 0.80 | TSHR (0.47) | CNR2GRM5 | |
| SCHEMBL19706271 | 0.78 | CNR2 (0.36) | BRAFCNR2CNR1KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |