Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 8/20 | 0.38 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 6/20 | 0.35 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365566 | 0.93 | RHOA (0.36) | KDM1ARHOAPIM1BRAFKDR | |
| SCHEMBL19706268 | 0.89 | RHOA (0.46) | KDM1ARHOAMAOBMAOABRAF | |
| SCHEMBL19670539 | 0.89 | BRAF (0.37) | KDM1ARHOAPIM1PIM2MAOB | |
| SCHEMBL19670632 | 0.88 | RHOA (0.39) | KDM1ARHOAPIM1FLT3PIM2 | |
| SCHEMBL19670282 | 0.87 | RHOA (0.40) | KDM1ARHOAPIM1FLT3PIM2 | |
| SCHEMBL19365783 | 0.83 | RHOA (0.45) | KDM1ARHOABRAFFYNRAF1 | |
| SCHEMBL20631976 | 0.83 | RHOA (0.37) | KDM1ARHOAPIM1FLT3PIM2 | |
| SCHEMBL16249945 | 0.82 | RHOA (0.37) | KDM1ARHOAPIM1FLT3PIM2 | |
| SCHEMBL19365660 | 0.82 | DYRK1A (0.37) | RHOAPIM1BRAF | |
| SCHEMBL19706028 | 0.82 | RHOA (0.36) | KDM1ARHOAPIM1FLT3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |