Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706131 | 0.88 | POLB (0.42) | CNR2GRM5FAAHKMOALDH1A1 | |
| SCHEMBL19706083 | 0.87 | MPL (0.44) | MPLFAAHKMOALDH1A1KDM1A | |
| SCHEMBL19706149 | 0.85 | FAAH (0.40) | CNR2GRM5FAAHALDH1A1KDM1A | |
| SCHEMBL19706127 | 0.83 | TSHR (0.47) | CNR2GRM5ALDH1A1ABL1 | |
| SCHEMBL19670550 | 0.82 | RHOA (0.39) | CNR2GRM5 | |
| SCHEMBL19365860 | 0.82 | CHRNA7 (0.36) | MPLFAAHKDM1AMAOBABL1 | |
| SCHEMBL19670539 | 0.80 | BRAF (0.37) | CNR2GRM5KDM1AMAOB | |
| SCHEMBL19706271 | 0.80 | CNR2 (0.36) | CNR2GRM5FAAHKDM1AMAOB | |
| SCHEMBL19706246 | 0.80 | BRAF (0.37) | CNR2GRM5KDM1AMAOBABL1 | |
| SCHEMBL19706141 | 0.80 | P2RY1 (0.40) | CNR2GRM5ALDH1A1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |