Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.30 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706298 | 0.90 | RHOA (0.38) | RHOACA2CA9CCR3TRPV1 | |
| SCHEMBL17624671 | 0.86 | RHOA (0.38) | RHOAGPR119RORCCA2CA9 | |
| SCHEMBL17624583 | 0.86 | RHOA (0.37) | RHOAGPR119RORCCCR3IRAK1 | |
| SCHEMBL19365867 | 0.86 | RHOA (0.37) | RHOAGPR119RORCCCR3IRAK1 | |
| SCHEMBL16785596 | 0.84 | RHOA (0.37) | RHOAGPR119RORCCA2CA9 | |
| SCHEMBL19365701 | 0.83 | RHOA (0.35) | RHOAGPR119RORCCCR3IRAK1 | |
| SCHEMBL17624672 | 0.82 | RHOA (0.35) | RHOAGPR119RORCCCR3 | |
| SCHEMBL17618871 | 0.82 | RHOA (0.35) | RHOARORCCCR3 | |
| SCHEMBL17618873 | 0.82 | RHOA (0.36) | RHOARORCIRAK1TRPV1 | |
| SCHEMBL19365585 | 0.81 | RHOA (0.40) | RHOACA2CA9CCR3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |