Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 13/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754506 | 1.00 | HCRTR1 (0.41) | HCRTR1HCRTR2CYP2C19PIK3CAMAPK1 | |
| SCHEMBL16754474 | 0.88 | ABL1 (0.38) | MAPK1ABL1 | |
| SCHEMBL16754278 | 0.88 | WNT3A (0.40) | ABL1 | |
| SCHEMBL16238798 | 0.88 | WNT3A (0.40) | ABL1 | |
| SCHEMBL17778385 | 0.88 | WNT3A (0.40) | ABL1 | |
| SCHEMBL16754298 | 0.87 | WNT3A (0.38) | HCRTR1MAPK1ABL1 | |
| SCHEMBL17618717 | 0.87 | SMO (0.38) | PIK3CAMAPK1ABL1 | |
| SCHEMBL17618513 | 0.86 | HCRTR1 (0.42) | HCRTR1MAPK1ABL1 | |
| SCHEMBL19699129 | 0.86 | WNT3A (0.41) | HCRTR1ABL1 | |
| SCHEMBL17770584 | 0.85 | ABL1 (0.36) | MAPK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |