Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.30 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19671926 | 0.78 | VNN1 (0.32) | KCNK2KCNK10VNN1HDAC6 | |
| SCHEMBL19672102 | 0.76 | VNN1 (0.31) | KCNK2KCNK10VNN1 | |
| SCHEMBL21416790 | 0.76 | KCNN4 (0.32) | VNN1KCNN4HDAC6 | |
| SCHEMBL20418717 | 0.73 | VNN1 (0.32) | VNN1KCNN4 | |
| SCHEMBL19671910 | 0.71 | LRRK2 (0.31) | — | |
| SCHEMBL19672014 | 0.70 | PIK3CA (0.43) | — | |
| SCHEMBL3182764 | 0.69 | KDM1A (0.32) | — | |
| SCHEMBL19671830 | 0.68 | ALDH1A1 (0.46) | — | |
| SCHEMBL19416920 | 0.68 | — | — | |
| SCHEMBL19671998 | 0.67 | KAT6A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964221-B1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME (US) | 2017-12-06 | — | — | EP | disclosed |