Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 13/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1967345 | 1.00 | HIF1A (0.45) | HIF1AEGLN3EGLN1EGLN2KDM4E | |
| SCHEMBL1969464 | 0.94 | ITGB1 (0.41) | HIF1AEGLN1KDM4EMAPK1HTT | |
| SCHEMBL1969468 | 0.94 | ITGB1 (0.41) | HIF1AEGLN1KDM4EMAPK1HTT | |
| SCHEMBL1967710 | 0.89 | EGLN3 (0.37) | EGLN3EGLN1EGLN2 | |
| SCHEMBL1970228 | 0.89 | HIF1A (0.52) | HIF1AEGLN3EGLN1EGLN2KDM4E | |
| SCHEMBL1967712 | 0.89 | EGLN3 (0.37) | EGLN3EGLN1EGLN2 | |
| SCHEMBL1971041 | 0.84 | EGLN1 (0.53) | HIF1AEGLN3EGLN1EGLN2 | |
| SCHEMBL1966695 | 0.83 | FEN1 (0.40) | HIF1AEGLN1KDM4EMAPK1HTT | |
| SCHEMBL1965504 | 0.83 | ITGA4 (0.40) | HIF1AEGLN3EGLN1EGLN2SMN1; SMN2 | |
| SCHEMBL1965503 | 0.83 | ITGA4 (0.40) | HIF1AEGLN3EGLN1EGLN2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | claimed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |