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Sugi Predict / Compounds / SCHEMBL1969468

SCHEMBL1969468

SCHEMBL1969468

CC[C@H](NC(=O)c1c(O)c2cc(Cl)cn2n(Cc2ccc(OC)cc2)c1=O)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ITGB1 P05556 9/20 0.41
▸ ITGA4 P13612 9/20 0.41
▸ ITGB7 P26010 5/20 0.41
▸ KDM4E B2RXH2 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ EGLN1 Q9GZT9 1/20 0.38
▸ FEN1 P39748 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ ERCC5 P28715 2/20 0.37
▸ HIF1A Q16665 1/20 0.37
▸ PPARD Q03181 1/20 0.36
▸ PPARA Q07869 1/20 0.36
▸ CA2 P00918 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1969464 1.00 ITGB1 (0.41) ITGB1ITGA4ITGB7KDM4EMAPK1
SCHEMBL1967342 0.94 HIF1A (0.45) KDM4EMAPK1HTTSMN1; SMN2EGLN1
SCHEMBL1967345 0.94 HIF1A (0.45) KDM4EMAPK1HTTSMN1; SMN2EGLN1
SCHEMBL1967712 0.92 EGLN3 (0.37) ITGB1ITGA4ITGB7EGLN1MEN1
SCHEMBL1967710 0.92 EGLN3 (0.37) ITGB1ITGA4ITGB7EGLN1MEN1
SCHEMBL1965504 0.89 ITGA4 (0.40) ITGB1ITGA4ITGB7SMN1; SMN2EGLN1
SCHEMBL1966699 0.89 FEN1 (0.40) ITGB1ITGA4ITGB7KDM4EMAPK1
SCHEMBL1965503 0.89 ITGA4 (0.40) ITGB1ITGA4ITGB7SMN1; SMN2EGLN1
SCHEMBL1966695 0.89 FEN1 (0.40) ITGB1ITGA4ITGB7KDM4EMAPK1
SCHEMBL1970228 0.84 HIF1A (0.52) KDM4EMAPK1HTTSMN1; SMN2EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2334682-B1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS FIBROGEN INC (US) 2017-10-04 — — EP claimed
US-8217043-B2 Compounds and methods for their use FIBROGEN, INC. (US) 2012-07-10 — — US claimed
EP-2334682-A1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS Fibrogen, Inc. (US) 2011-06-22 — — EP claimed
WO-2010022240-A1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS FIBROGEN, INC. (US) 2010-02-25 — — WO claimed
US-20100047367-A1 COMPOUNDS AND METHODS FOR THEIR USE FIBROGEN, INC. 2010-02-25 — — US claimed
EP-2334682-B1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS FIBROGEN INC (US) 2017-10-04 — — EP disclosed
US-8217043-B2 Compounds and methods for their use FIBROGEN, INC. (US) 2012-07-10 — — US disclosed
EP-2334682-A1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS Fibrogen, Inc. (US) 2011-06-22 — — EP disclosed
WO-2010022240-A1 PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS FIBROGEN, INC. (US) 2010-02-25 — — WO disclosed
US-20100047367-A1 COMPOUNDS AND METHODS FOR THEIR USE FIBROGEN, INC. 2010-02-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100047367-A1 COMPOUNDS AND METHODS FOR THEIR USE HIF1AN, HIF1A, EGLN3 ITGB1 4730/4885ITGA4 4690/4885ITGB7 4501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.