Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.41 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.41 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.41 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403247 | 0.78 | SIGMAR1 (0.52) | SIGMAR1CHI3L1CHIT1CHI3L2CHIA | |
| SCHEMBL2405529 | 0.75 | SIGMAR1 (0.44) | KDM4EALDH1A1SIGMAR1FAAH | |
| SCHEMBL8367478 | 0.74 | CNR1 (0.40) | CYP19A1HCRTR1HCRTR2PDE2ASLC6A4 | |
| SCHEMBL22657573 | 0.72 | CTNNB1 (0.41) | CYP19A1HCRTR1HCRTR2SLC6A4DRD4 | |
| SCHEMBL27044834 | 0.71 | SKP2 (0.42) | ALDH1A1CYP19A1SLC6A4FAAH | |
| SCHEMBL1970890 | 0.71 | CHIT1 (0.47) | ALDH1A1SIGMAR1CHI3L1CHIT1CHI3L2 | |
| SCHEMBL22657669 | 0.71 | CTNNB1 (0.43) | KDM4EALDH1A1CYP19A1SLC6A4FAAH | |
| SCHEMBL1969047 | 0.71 | TAAR1 (0.60) | SIGMAR1CHI3L1CHIT1CHI3L2CHIA | |
| SCHEMBL1971747 | 0.71 | TAAR1 (0.53) | KDM4EALDH1A1CYP19A1SLC6A4DRD4 | |
| SCHEMBL2663369 | 0.70 | CTNNB1 (0.41) | CYP19A1HCRTR1HCRTR2SLC6A4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | KDM4E 452/4885ALDH1A1 2292/4885SIGMAR1 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.