Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032915 | 0.91 | RECQL (0.52) | RECQLPRMT5WDR77HPGDUSP2 | |
| SCHEMBL3332529 | 0.89 | HPGD (0.47) | PIK3CDRECQLPRMT5WDR77HPGD | |
| SCHEMBL15802795 | 0.89 | HPGD (0.47) | PIK3CDRECQLPRMT5WDR77HPGD | |
| SCHEMBL3332523 | 0.89 | HPGD (0.47) | PIK3CDRECQLPRMT5WDR77HPGD | |
| SCHEMBL19852541 | 0.87 | USP30 (0.45) | PIK3CDRECQLPRMT5WDR77HPGD | |
| SCHEMBL18839712 | 0.85 | USP30 (0.46) | PIK3CDRECQLPRMT5WDR77HPGD | |
| SCHEMBL28597394 | 0.85 | USP30 (0.46) | PIK3CDRECQLPRMT5WDR77HPGD | |
| SCHEMBL28585597 | 0.85 | USP30 (0.46) | PIK3CDRECQLPRMT5WDR77HPGD | |
| SCHEMBL18839609 | 0.85 | USP30 (0.46) | PIK3CDRECQLPRMT5WDR77HPGD | |
| SCHEMBL18839607 | 0.85 | USP30 (0.46) | PIK3CDRECQLPRMT5WDR77HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794600-B1 | 2,3-Dihydro-benzo[1,4]oxazine derivatives and related compounds as phosphoinositide-3 kinase (PI3K) inhibitors for the treatment of e.g. rheumatoid arthritis | NOVARTIS AG (CH) | 2017-12-06 | — | — | EP | disclosed |