Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28299833 | 0.72 | NISCH (0.44) | MAOBNISCHRAB9AMAOA | |
| Biphenyl SCHEMBL27470407 | 0.71 | NPC1 (0.53) | NPC1MAPTRAB9A | |
| SCHEMBL26984249 | 0.67 | CHRNB4 (0.38) | MAOBCA1CA2NISCHMAPT | |
| SCHEMBL28559384 | 0.67 | MAOB (0.43) | MAOBNISCHMAPTMAOA | |
| SCHEMBL7598305 | 0.66 | — | — | |
| SCHEMBL14528226 | 0.66 | MEN1 (0.42) | MAOBACHEKIF11NPC1RAB9A | |
| SCHEMBL434294 | 0.65 | MTNR1A (0.47) | — | |
| SCHEMBL9228731 | 0.64 | CHRNB4 (0.36) | MAOBCA1CA2NISCHNPC1 | |
| Biphenyl SCHEMBL29059196 | 0.62 | SMN1; SMN2 (0.67) | NPC1MAPTRAB9ALMNA | |
| Biphenyl SCHEMBL1822628 | 0.62 | SMN1; SMN2 (0.67) | NPC1MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |