Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL538359 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL15332958 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL11759013 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL1308540 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Acetic Acid SCHEMBL27559163 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL1157851 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL31099242 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL4205333 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL8025407 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 | |
| Biphenyl SCHEMBL11131611 | 0.97 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1L3MBTL1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113636994-B | Novel method for preparing biphenyl dianhydride by continuous flow micro-channel reaction system | 哈尔滨工业大学（威海） | 2023-08-25 | — | — | CN | claimed |
| CN-113636994-B | Novel method for preparing biphenyl dianhydride by continuous flow micro-channel reaction system | 哈尔滨工业大学（威海） | 2023-08-25 | — | — | CN | disclosed |