Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MPO | P05164 | 3/20 | 0.43 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2807490 | 0.86 | REN (0.49) | MPORENKDM4CKDM4EALDH1A1 | |
| SCHEMBL30860197 | 0.82 | SCN9A (0.48) | KMT2AMEN1SMN1; SMN2MPOREN | |
| SCHEMBL15882095 | 0.80 | KDM4C (0.49) | KMT2AMEN1RENKDM4CKDM4E | |
| SCHEMBL17324732 | 0.80 | REN (0.44) | KMT2AMEN1SMN1; SMN2MPOREN | |
| SCHEMBL8242095 | 0.79 | GLS (0.45) | KMT2ASMN1; SMN2MPOKDM4CKDM4E | |
| SCHEMBL17321433 | 0.77 | KDM4E (0.47) | RENKDM4CKDM4E | |
| SCHEMBL15882528 | 0.76 | ELANE (0.56) | KDM4E | |
| SCHEMBL30860242 | 0.75 | REN (0.39) | KMT2AMEN1SMN1; SMN2MPOREN | |
| SCHEMBL13131353 | 0.74 | REN (0.47) | MPORENKDM4CKDM4EALDH1A1 | |
| SCHEMBL14158232 | 0.74 | NPC1 (0.43) | KMT2AMEN1SMN1; SMN2MPOREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |