Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15882147 | 0.85 | NR4A2 (0.72) | NR4A2GAALMNASMN1; SMN2MAPT | |
| SCHEMBL19675355 | 0.85 | ALDH1A1 (0.57) | NR4A2LMNAMAPTL3MBTL1KMT2A | |
| SCHEMBL31429438 | 0.82 | NR4A2 (0.76) | NR4A2GAALMNASMN1; SMN2MAPT | |
| SCHEMBL19675319 | 0.82 | CNR1 (0.48) | NR4A2CNR1BRD4KDM4E | |
| SCHEMBL19675182 | 0.82 | ALDH1A1 (0.64) | NR4A2GAALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL1855462 | 0.80 | NR4A2 (1.00) | NR4A2GAALMNASMN1; SMN2MAPT | |
| SCHEMBL6297494 | 0.79 | NR4A2 (0.76) | NR4A2GAALMNASMN1; SMN2MAPT | |
| SCHEMBL2042864 | 0.79 | NR4A2 (0.71) | NR4A2GAALMNASMN1; SMN2MAPT | |
| SCHEMBL2948572 | 0.78 | NR4A2 (0.65) | NR4A2GAALMNASMN1; SMN2MAPT | |
| SCHEMBL6984456 | 0.78 | NR4A2 (0.78) | NR4A2GAALMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |