Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5066705 | 0.85 | ALDH1A1 (0.58) | ALDH1A1KDM4EL3MBTL1MAPK1PLK1 | |
| SCHEMBL19675353 | 0.85 | NR4A2 (0.67) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL19675182 | 0.85 | ALDH1A1 (0.64) | ALDH1A1KDM4EL3MBTL1MAPK1KMT2A | |
| SCHEMBL15882924 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KDM4EL3MBTL1MAPK1PLK1 | |
| SCHEMBL31429390 | 0.79 | KDM4E (0.58) | ALDH1A1KDM4EL3MBTL1MAPK1PLK1 | |
| SCHEMBL30373303 | 0.79 | NR4A2 (0.69) | ALDH1A1KDM4EL3MBTL1PLK1MAPT | |
| SCHEMBL2429622 | 0.79 | NR4A2 (0.69) | ALDH1A1KDM4EL3MBTL1PLK1MAPT | |
| SCHEMBL2035148 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KDM4EL3MBTL1MAPK1PLK1 | |
| SCHEMBL2035739 | 0.77 | KDM4E (0.56) | ALDH1A1KDM4EL3MBTL1MAPK1PLK1 | |
| SCHEMBL5065671 | 0.76 | CNR2 (0.68) | ALDH1A1PLK1MAPTCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |