Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20250882 | 0.91 | ROCK2 (0.42) | ROCK2PLA2G4A | |
| SCHEMBL17324670 | 0.87 | ROCK2 (0.47) | ROCK2ROCK1RETKIT | |
| SCHEMBL15882328 | 0.85 | ROCK2 (0.47) | ROCK2ROCK1RETKIT | |
| SCHEMBL19675109 | 0.85 | L3MBTL1 (0.43) | PLA2G4A | |
| SCHEMBL15882285 | 0.84 | ROCK2 (0.46) | ROCK2 | |
| SCHEMBL17321449 | 0.82 | ROCK2 (0.45) | ROCK2ROCK1RET | |
| SCHEMBL20646745 | 0.79 | ROCK2 (0.40) | ROCK2 | |
| SCHEMBL23889140 | 0.79 | KMT2A (0.35) | ROCK2PLA2G4A | |
| SCHEMBL19902675 | 0.78 | ROCK2 (0.47) | ROCK2 | |
| SCHEMBL24247821 | 0.76 | EGLN1 (0.36) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |