Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19675273 | 0.80 | HDAC3 (0.35) | MAPTALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL611411 | 0.79 | MAPT (0.53) | MAPTALDH1A1NPSR1ALOX15L3MBTL1 | |
| SCHEMBL10472733 | 0.78 | ALDH1A1 (0.57) | MAPTALDH1A1NPSR1ALOX15L3MBTL1 | |
| SCHEMBL15893978 | 0.78 | HIF1A (0.58) | MAPTALDH1A1NPSR1ALOX15L3MBTL1 | |
| SCHEMBL609043 | 0.77 | ALDH1A1 (0.56) | MAPTALDH1A1NPSR1ALOX15L3MBTL1 | |
| SCHEMBL611035 | 0.77 | ALDH1A1 (0.56) | MAPTALDH1A1NPSR1ALOX15L3MBTL1 | |
| SCHEMBL8461563 | 0.77 | MAPT (0.35) | MAPTNPSR1SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL7907741 | 0.76 | HIF1A (0.61) | MAPTALDH1A1NPSR1ALOX15L3MBTL1 | |
| SCHEMBL10473961 | 0.76 | ALDH1A1 (0.60) | MAPTALDH1A1NPSR1ALOX15L3MBTL1 | |
| SCHEMBL10472913 | 0.76 | ALDH1A1 (0.60) | MAPTALDH1A1NPSR1ALOX15L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |