Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 9/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23511710 | 0.77 | AR (0.47) | ARCHEK1PARP1LMNATSHR | |
| SCHEMBL13180313 | 0.70 | AR (0.54) | ARCHEK1PARP1LMNAPOLB | |
| SCHEMBL31014280 | 0.70 | NPSR1 (0.62) | ARCHEK1PARP1LMNATSHR | |
| SCHEMBL4572048 | 0.70 | ALDH1A1 (0.59) | CHEK1PARP1LMNAPOLB | |
| SCHEMBL30719649 | 0.69 | LMNA (0.50) | ARCHEK1PARP1LMNATSHR | |
| SCHEMBL23496955 | 0.69 | LMNA (0.50) | ARCHEK1PARP1LMNATSHR | |
| SCHEMBL14310776 | 0.69 | AR (0.49) | ARCHEK1PARP1LMNAATM | |
| SCHEMBL8548318 | 0.69 | AR (0.46) | ARCHEK1LMNATSHRATM | |
| SCHEMBL6332425 | 0.68 | CHEK1 (0.42) | ARCHEK1LMNATSHRPRMT5 | |
| SCHEMBL16136132 | 0.68 | PARP1 (0.53) | ARPARP1LMNAPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |