Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 8/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.40 |
| ▸ | MERTK | Q12866 | 3/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19675858 | 0.83 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDHSD17B10SIRT5 | |
| SCHEMBL17197228 | 0.82 | LRRK2 (0.45) | KDM4CHCAR3JAK2KDM4EHPGD | |
| SCHEMBL15584085 | 0.79 | FLT3 (0.58) | KDM6BKDM4CJAK3JAK1JAK2 | |
| SCHEMBL2023250 | 0.78 | ALDH1A1 (0.57) | KDM6BKDM4CHCAR3KDM4EALDH1A1 | |
| SCHEMBL15584094 | 0.78 | AURKA (0.54) | JAK3JAK1JAK2 | |
| SCHEMBL15584991 | 0.78 | KDM6B (0.47) | KDM6BKDM4CJAK3JAK1JAK2 | |
| SCHEMBL15584509 | 0.77 | SYK (0.43) | KDM6BKDM4CJAK3JAK1JAK2 | |
| SCHEMBL15584430 | 0.77 | SYK (0.50) | JAK3JAK1JAK2MERTKSIRT5 | |
| SCHEMBL7216937 | 0.76 | PDE5A (0.53) | KDM6BKDM4CHCAR3KDM4EALDH1A1 | |
| SCHEMBL15584512 | 0.76 | SIRT5 (0.58) | JAK3JAK1JAK2SIRT5FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2840080-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF | FUJIFILM CORP (JP) | 2017-12-06 | — | — | EP | disclosed |