Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 15/20 | 0.52 |
| ▸ | DRD2 | P14416 | 14/20 | 0.52 |
| ▸ | DRD3 | P35462 | 11/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15637880 | 0.81 | DRD4 (0.52) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL18708556 | 0.79 | DRD4 (0.50) | DRD4DRD2DRD3GAA | |
| SCHEMBL19574376 | 0.74 | SCN5A (0.42) | — | |
| SCHEMBL18708229 | 0.73 | KDM5B (0.40) | CHRM2 | |
| SCHEMBL11896615 | 0.72 | DRD4 (1.00) | DRD4DRD2DRD3GAA | |
| Hydrochloric Acid SCHEMBL8055377 | 0.71 | DRD4 (0.96) | DRD4DRD2DRD3GAA | |
| SCHEMBL10476759 | 0.71 | DRD4 (0.95) | DRD4DRD2DRD3GAA | |
| SCHEMBL19549135 | 0.70 | KDM5B (0.48) | CHRM2 | |
| Hydrochloric Acid SCHEMBL8054973 | 0.69 | DRD4 (0.91) | DRD4DRD2DRD3GAA | |
| SCHEMBL8938905 | 0.69 | DRD4 (0.91) | DRD4DRD2DRD3ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |