Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.42 |
| ▸ | KDM5C | P41229 | 8/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 9/20 | 0.39 |
| ▸ | KDM4A | O75164 | 5/20 | 0.39 |
| ▸ | KDM5A | P29375 | 4/20 | 0.39 |
| ▸ | KDM6B | O15054 | 4/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16310760 | 0.77 | KDM5B (0.49) | KDM4DKDM5CKDM4CKDM5BKDM4A | |
| SCHEMBL15636891 | 0.77 | KDM5B (0.49) | KDM4DKDM5CKDM4CKDM5BKDM4A | |
| SCHEMBL16291806 | 0.72 | KDM5B (0.53) | KDM4DKDM5CKDM4CKDM5BKDM4A | |
| SCHEMBL16055909 | 0.72 | MAPK1 (0.47) | KDM4DKDM5CKDM4CKDM5BKDM4A | |
| SCHEMBL2305108 | 0.70 | KDM4C (0.57) | KDM4DKDM5CKDM4CKDM5BKDM4A | |
| SCHEMBL16055756 | 0.70 | KDM4E (0.65) | KDM4DKDM5CKDM4CKDM5BKDM4A | |
| SCHEMBL481039 | 0.70 | KDM4C (0.52) | KDM4DKDM5CKDM4CKDM5BKDM4A | |
| SCHEMBL17144250 | 0.69 | CYP2D6 (0.46) | KDM5CKDM4CKDM5BKDM4AKDM5A | |
| SCHEMBL31313383 | 0.68 | GRIN2D (0.48) | KDM4DKDM5CKDM4CKDM5BKDM4A | |
| SCHEMBL7670706 | 0.67 | KDM4C (0.57) | KDM4DKDM5CKDM4CKDM5BKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |