Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.52 |
| ▸ | KDM5C | P41229 | 7/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | KDM5A | P29375 | 6/20 | 0.52 |
| ▸ | KDM4A | O75164 | 5/20 | 0.52 |
| ▸ | KDM6B | O15054 | 4/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.52 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.52 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.52 |
| ▸ | TET3 | O43151 | 1/20 | 0.52 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ASPH | Q12797 | 1/20 | 0.52 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.52 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.52 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.52 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31191238 | 0.85 | KDM4C (0.55) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| SCHEMBL845767 | 0.85 | KDM4C (0.55) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| SCHEMBL16055756 | 0.82 | KDM4E (0.65) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| SCHEMBL28561977 | 0.80 | KDM4E (0.53) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| SCHEMBL7670706 | 0.79 | KDM4C (0.57) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| SCHEMBL2305108 | 0.79 | KDM4C (0.57) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| SCHEMBL16055788 | 0.79 | KDM5B (0.63) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| SCHEMBL27542831 | 0.79 | KDM4C (0.63) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| SCHEMBL13518765 | 0.79 | KDM4E (0.44) | KDM4CKDM5CKDM5BKDM4EKDM5A | |
| Hydrochloric Acid SCHEMBL30523486 | 0.78 | KDM4C (0.61) | KDM4CKDM5CKDM5BKDM4EKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411361-B1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-06-18 | — | — | EP | disclosed |
| US-8138189-B2 | Substituted benzene compounds as modulators of the glucocorticoid receptor | HOFFMAN-LA ROCHE INC. (US) | 2012-03-20 | — | — | US | disclosed |
| EP-2411361-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-01 | — | — | EP | disclosed |
| US-20100249139-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN-LA ROCHE, INC. | 2010-09-30 | — | — | US | disclosed |
| WO-2010108902-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249139-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | NR3C1, NR3C2, CRHR1 | KDM4C 3615/4885KDM5C 3245/4885KDM5B 3235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.