Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAUR | Q03405 | 3/20 | 0.70 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15939902 | 0.80 | KMT2A (0.76) | MEN1KMT2APOLBAPAF1USP2 | |
| SCHEMBL19687291 | 0.77 | NR1H4 (0.47) | PLAURKMT2AUSP2TSHRNR1H4 | |
| SCHEMBL12698666 | 0.76 | PLAUR (1.00) | PLAURPLAUNTRK1MEN1KMT2A | |
| SCHEMBL2483448 | 0.73 | EHMT2 (0.61) | PLAURPLAUNTRK1MEN1KMT2A | |
| SCHEMBL2628847 | 0.73 | NTRK1 (0.74) | PLAURPLAUNTRK1POLBEHMT2 | |
| SCHEMBL13285004 | 0.72 | NTRK1 (0.62) | PLAURPLAUNTRK1MEN1KMT2A | |
| SCHEMBL17874500 | 0.70 | PLAU (0.81) | PLAURPLAUNTRK1EHMT2MAPT | |
| SCHEMBL15940016 | 0.69 | MEN1 (0.74) | PLAURMEN1KMT2APOLBAPAF1 | |
| SCHEMBL12499325 | 0.69 | PLAU (1.00) | PLAURPLAUNTRK1EHMT2MAPT | |
| SCHEMBL30019219 | 0.69 | PLAU (1.00) | PLAURPLAUNTRK1EHMT2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348266-A1 | INHIBITION OF PROLINE CATABOLISM FOR THE TREATMENT OF CANCER AND OTHER THERAPEUTIC APPLICATIONS | BUCK INSTITUTE FOR RESEARCH ON AGING | 2017-12-07 | — | — | US | disclosed |
| US-20170348266-A1 | INHIBITION OF PROLINE CATABOLISM FOR THE TREATMENT OF CANCER AND OTHER THERAPEUTIC APPLICATIONS | BUCK INSTITUTE FOR RESEARCH ON AGING | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348266-A1 | INHIBITION OF PROLINE CATABOLISM FOR THE TREATMENT OF CANCER AND OTHER THERAPEUTIC APPLICATIONS | GLUL, GLS2, PHGDH | PLAUR 2892/4885PLAU 2041/4885NTRK1 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.