Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Urea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL10426486 | 0.82 | TP53 (0.78) | TP53ALDH1A1OR51E2LMNATDP1 | |
| Sulfuric Acid SCHEMBL10426485 | 0.82 | TP53 (0.78) | TP53ALDH1A1OR51E2LMNATDP1 | |
| Hydrochloric Acid SCHEMBL11848392 | 0.80 | TP53 (0.53) | TP53ALDH1A1LMNATDP1 | |
| Hydrochloric Acid SCHEMBL196471 | 0.80 | TP53 (0.53) | TP53ALDH1A1LMNATDP1 | |
| Sulfuric Acid SCHEMBL15309084 | 0.80 | TP53 (0.65) | TP53ALDH1A1OR51E2LMNATDP1 | |
| Urea SCHEMBL17104444 | 0.79 | LMNA (0.43) | TP53ALDH1A1OR51E2LMNATDP1 | |
| Thiourea SCHEMBL29203675 | 0.79 | TSHR (0.43) | TP53 | |
| Hydrochloric Acid SCHEMBL9635212 | 0.76 | TP53 (0.50) | TP53ALDH1A1LMNATDP1 | |
| SCHEMBL29465010 | 0.76 | — | — | |
| SCHEMBL29465011 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115652471-A | Flame-retardant polyester filament yarn and production process thereof | 安徽融泰再生资源有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-216423676-U | Environment-friendly flame-retardant knitted subbottom super-imitation fabric | 福建中裕新材料技术有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-114016282-A | Manufacturing method of flame-retardant antibacterial polyester-cotton blended fabric | 上海欧蓓实业有限公司 | 2022-02-08 | — | — | CN | claimed |
| CN-112776438-A | High-flame-retardancy fabric and preparation method thereof | 新乡市护神特种织物有限公司 | 2021-05-11 | — | — | CN | claimed |
| CN-112281485-A | Preparation method of moisture-absorbing quick-drying flame-retardant knitted fabric | 新乡市护神特种织物有限公司 | 2021-01-29 | — | — | CN | claimed |
| CN-112281484-A | Preparation method of moisture-absorbing quick-drying flame-retardant fabric | 新乡市护神特种织物有限公司 | 2021-01-29 | — | — | CN | claimed |
| CN-107675515-B | Nano-cellulose reinforced packing material and preparation method thereof | 山东沃源新型面料股份有限公司 | 2020-06-23 | — | — | CN | claimed |
| US-9945068-B2 | Flame retardant fabrics and methods for manufacturing the same | Matchmaster Dyeing & Finishing, Inc. (US) | 2018-04-17 | — | — | US | claimed |
| CN-103788407-B | The preparation method of the pillared phyllosilicate flame retardant of a kind of porous | SHANGHAI UNIVERSITY OF ENGINEERING SCIENCE (CN) | 2016-03-16 | — | — | CN | claimed |
| CN-103834197-B | Preparation method of organic montmorillonite modified by supermolecular liquid crystal polymer | UNIV SHANGHAI ENG SCIENCE | 2015-04-08 | — | — | CN | claimed |
| US-20140045399-A1 | FLAME RETARDANT FABRICS AND METHODS FOR MANUFACTURING THE SAME | Matchmaster Dyeing & Finishing, Inc. (US) | 2014-02-13 | — | — | US | claimed |
| CN-102180905-B | Preparation method of tetrakis(hydroxymethyl)phosphonium chloride-urea precondensate | CHANGSHU NEW TECH CHEMICALS CO LTD | 2013-11-06 | — | — | CN | claimed |
| US-8557347-B1 | Flame retardant fabrics and methods for manufacturing the same | Matchmaster Dyeing & Finishing, Inc. (US) | 2013-10-15 | — | — | US | claimed |
| CN-102604160-B | Organic montmorillonoid flame retardant with high heat resistance and high smoke suppression as well as preparation method thereof | UNIV SHANGHAI ENG SCIENCE | 2013-04-10 | — | — | CN | claimed |
| CN-102180905-A | Preparation method of tetrakis(hydroxymethyl)phosphonium chloride-urea precondensate | CHANGSHU NEW TECH CHEMICALS CO LTD | 2011-09-14 | — | — | CN | claimed |
| CN-101134763-A | Method for preparing tetra hydroxymethyl phosphorus trichloride-urea primary condensed polymer | JIANGSU KANGXIANG GROUP CORP (CN) | 2008-03-05 | — | — | CN | claimed |
| CN-1022937-C | Comfortable fabrics of high durability | DU PONT (US) | 1993-12-01 | — | — | CN | claimed |
| CN-1050060-A | High-durability, fabric comfortable and easy to wear | DU PONT (US) | 1991-03-20 | — | — | CN | claimed |
| EP-0412196-A1 | Comfortable fabrics of high durability | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-02-13 | — | — | EP | claimed |
| US-4941884-A | WEAR RESISTANT WOVEN FABRICS TREATED WITH SHRINKAGE TO IMPROVE DURABILITY | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-07-17 | — | — | US | claimed |