Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 5/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637023 | 0.87 | KIT (0.46) | PDGFRBACHEBACE1KRASPDGFRA | |
| SCHEMBL16637022 | 0.85 | KRAS (0.39) | PDGFRBKRASPDGFRA | |
| SCHEMBL22631329 | 0.80 | KRAS (0.48) | PDGFRBKRAS | |
| SCHEMBL21839989 | 0.76 | PDGFRB (0.49) | PDGFRBACHEBACE1KRASPDGFRA | |
| SCHEMBL16637875 | 0.74 | PDGFRB (0.49) | PDGFRBACHEBACE1KRASPDGFRA | |
| SCHEMBL16637244 | 0.71 | KRAS (0.52) | PDGFRBACHEBACE1KRAS | |
| SCHEMBL22029069 | 0.71 | ACHE (0.44) | PDGFRBACHEBACE1KRASPDGFRA | |
| SCHEMBL7973030 | 0.70 | PDGFRB (0.66) | PDGFRBACHEBACE1PDGFRA | |
| SCHEMBL16637970 | 0.70 | PDGFRB (0.51) | PDGFRBKRAS | |
| SCHEMBL16637905 | 0.70 | PDGFRB (0.46) | PDGFRBACHEBACE1KRASPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840516-B2 | Substituted quinazolines as inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2017-12-12 | — | — | US | disclosed |