Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 16/20 | 0.59 |
| ▸ | FEN1 | P39748 | 16/20 | 0.59 |
| ▸ | PARG | Q86W56 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628076 | 0.88 | ALOX5AP (0.59) | ALOX5APFEN1 | |
| SCHEMBL5885311 | 0.86 | ALOX5AP (0.58) | ALOX5APFEN1 | |
| SCHEMBL890585 | 0.86 | ALOX5AP (0.65) | ALOX5APFEN1 | |
| SCHEMBL7084914 | 0.86 | ALOX5AP (0.54) | ALOX5APFEN1PARG | |
| SCHEMBL890690 | 0.86 | ALOX5AP (0.54) | ALOX5APFEN1CASP1 | |
| Hydrochloric Acid SCHEMBL6175800 | 0.85 | ALOX5AP (0.64) | ALOX5APFEN1NSD2 | |
| SCHEMBL3831543 | 0.84 | ALOX5AP (0.60) | ALOX5APFEN1 | |
| SCHEMBL7190899 | 0.84 | ALOX5AP (0.55) | ALOX5APFEN1 | |
| SCHEMBL489577 | 0.84 | ALOX5AP (0.55) | ALOX5APFEN1 | |
| SCHEMBL2452804 | 0.84 | CASP1 (0.48) | ALOX5APFEN1EDNRBEDNRACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334651-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010011821-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2010-01-28 | — | — | WO | disclosed |
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | disclosed |
| EP-1824826-A4 | ARYL SULFONIC PYRIDOXINES AS ANTIPLATELET AGENTS | MEDICURE INT INC (BB) | 2009-06-03 | — | — | EP | disclosed |
| EP-1824826-A1 | ARYL SULFONIC PYRIDOXINES AS ANTIPLATELET AGENTS | Medicure International Inc. (BB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006045204-A1 | ARYL SULFONIC PYRIDOXINES AS ANTIPLATELET AGENTS | MEDICURE INTERNATIONAL INC. (CA) | 2006-05-04 | — | — | WO | disclosed |
| US-6548512-B1 | Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-15 | — | — | US | disclosed |
| US-6020357-A | CARDIOVASCULAR DISORDERS; ANTCOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0946508-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | Du Pont Pharmaceuticals Company (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028269-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-07-02 | — | — | WO | disclosed |
| US-5411980-A | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO., INC. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5281614-A | Hypotensive agents, glaucoma or angiotensin antagonists | MERCK & CO., INC. (US) | 1994-01-25 | — | — | US | disclosed |
| US-5262412-A | Angiotensin II antagonists, hypotensive agents, treatment of congestive heart failure and glaucoma | MERCK & CO., INC. (US) | 1993-11-16 | — | — | US | disclosed |