Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 17/20 | 0.55 |
| ▸ | FEN1 | P39748 | 17/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280981 | 0.87 | ALOX5AP (0.54) | ALOX5APFEN1OPRM1OPRK1 | |
| SCHEMBL6630002 | 0.87 | ALOX5AP (0.57) | ALOX5APFEN1OPRM1OPRK1 | |
| SCHEMBL7266374 | 0.85 | OPRM1 (0.54) | ALOX5APFEN1OPRM1OPRK1MMP3 | |
| SCHEMBL6974699 | 0.85 | ALOX5AP (0.53) | ALOX5APFEN1OPRM1OPRK1MMP3 | |
| SCHEMBL7266847 | 0.84 | ALOX5AP (0.55) | ALOX5APFEN1OPRM1OPRK1MMP3 | |
| SCHEMBL6771873 | 0.84 | EDNRA (0.58) | ALOX5APFEN1OPRM1OPRK1 | |
| SCHEMBL1968159 | 0.84 | ALOX5AP (0.59) | ALOX5APFEN1 | |
| SCHEMBL6628076 | 0.83 | ALOX5AP (0.59) | ALOX5APFEN1 | |
| SCHEMBL5885311 | 0.81 | ALOX5AP (0.58) | ALOX5APFEN1 | |
| SCHEMBL890585 | 0.81 | ALOX5AP (0.65) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | disclosed |
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | MERCK FROSST CANADA LTD. (CA) | 2002-07-11 | — | — | US | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | PTPRF, PTPRS, PTPRO | ALOX5AP 1114/4885FEN1 1769/4885OPRM1 4651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.