SCHEMBL19683350

SCHEMBL19683350

COC(COc1ccc2ccc(OCC(OC)OC)cc2c1)OC

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
AGXT P21549 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2A6 P11509 1/20 0.42
KDM4E B2RXH2 1/20 0.41
MAPK1 P28482 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
KDM1A O60341 2/20 0.41
RAB9A P51151 3/20 0.41
CD209 Q9NNX6 1/20 0.40
ALOX5 P09917 1/20 0.40
NPC1 O15118 1/20 0.39
CASR P41180 1/20 0.38
PTPN7 P35236 1/20 0.38
CYP2C9 P11712 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8798650 0.77 KDM4E (0.46) KDM4EMAPK1
SCHEMBL5962530 0.77 MAOB (0.41) CYP2C9TSHR
SCHEMBL7931690 0.77 CYP2C9 (0.60) KDM4EMAPK1CYP2C9TSHR
SCHEMBL1953356 0.77 ALDH1A1 (0.49) KDM4ERAB9AALOX5NPC1TSHR
SCHEMBL19852539 0.77 CYP3A4 (0.56) CYP1A2RAB9ANPC1
SCHEMBL19683357 0.77 NR2E1 (0.44) CYP1A2KDM4EMAPK1TDP1CYP2C9
SCHEMBL22838174 0.76 CYP1A2 (0.52) AGXTCYP1A2CYP2A6KDM4EMAPK1
SCHEMBL14065428 0.76 CA12 (0.66) CYP1A2KDM4ETDP1RAB9ANPC1
SCHEMBL17996498 0.75 TSHR (0.47) CYP1A2KDM4ENPC1CYP2C9TSHR
SCHEMBL6947144 0.74 KMT2A (0.39) RAB9ACYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017210072-A1 ELECTROACTIVE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2017-12-07 WO disclosed