SCHEMBL19683573

SCHEMBL19683573

Brc1cc2c3ccoc3c(Br)cc2c2ccoc12

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
HTR2B P41595 1/20 0.38
PTPN1 P18031 1/20 0.32
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6305380 0.78 HTR2A (0.32) HTR2AHTR2CHTR2B
SCHEMBL31553097 0.77 HTR2A (0.35) HTR2AHTR2CHTR2B
SCHEMBL23218517 0.76 KCNA3 (0.35) HTR2AHTR2CHTR2BPTPN1
SCHEMBL29591905 0.76 KCNA3 (0.35) HTR2AHTR2CHTR2BPTPN1
SCHEMBL4992632 0.76 GYS1 (0.30) HTR2AHTR2CHTR2B
SCHEMBL19056392 0.76 HTR2A (0.55) HTR2AHTR2CHTR2B
SCHEMBL1697007 0.75 ESR2 (0.40) HTR2AHTR2CHTR2BPTPN1ESR1
SCHEMBL30771800 0.74 PTPN1 (0.47) PTPN1ESR1ESR2
SCHEMBL29592513 0.73 HTR2A (0.33) HTR2AHTR2CHTR2BPTPN1
SCHEMBL23218688 0.73 HTR2A (0.33) HTR2AHTR2CHTR2BPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017210072-A1 ELECTROACTIVE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2017-12-07 WO disclosed