Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 13/20 | 0.58 |
| ▸ | FLT3 | P36888 | 8/20 | 0.58 |
| ▸ | CSF1R | P07333 | 4/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.58 |
| ▸ | KIT | P10721 | 4/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | FLT4 | P35916 | 2/20 | 0.58 |
| ▸ | CDK8 | P49336 | 2/20 | 0.58 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.58 |
| ▸ | CDK11B | P21127 | 1/20 | 0.58 |
| ▸ | CCNC | P24863 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20878850 | 0.87 | RET (0.55) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683818 | 0.86 | RET (0.58) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683602 | 0.84 | FLT3 (0.55) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL20878929 | 0.84 | RET (0.53) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683604 | 0.82 | EPHX2 (0.49) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL20878986 | 0.82 | EGFR (0.47) | RETPDGFRALCKBTKKDR | |
| SCHEMBL19683696 | 0.81 | FLT3 (0.59) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL20878898 | 0.81 | RET (0.52) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683764 | 0.81 | RET (0.52) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL20878886 | 0.80 | RAF1 (0.64) | FLT3RAF1BRAFRIPK2MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |
| EP-3466952-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | Precedo Pharmaceuticals Co., Ltd. (CN) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |