Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 14/20 | 0.58 |
| ▸ | FLT3 | P36888 | 7/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | CDK11B | P21127 | 1/20 | 0.58 |
| ▸ | CCNC | P24863 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20878850 | 0.87 | RET (0.55) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683600 | 0.86 | RET (0.58) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL20878929 | 0.85 | RET (0.53) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683816 | 0.84 | EGFR (0.42) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683604 | 0.82 | EPHX2 (0.49) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683602 | 0.82 | FLT3 (0.55) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683821 | 0.81 | BRAF (0.56) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL20878942 | 0.81 | EGFR (0.45) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL13234602 | 0.80 | RET (0.79) | RETFLT3CSF1RPDGFRBKIT | |
| SCHEMBL19683701 | 0.80 | FLT3 (0.44) | RETFLT3CSF1RPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |