Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | CDK11B | P21127 | 1/20 | 0.49 |
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683821 | 0.87 | BRAF (0.56) | EPHX2FLT3CSF1RRETPDGFRB | |
| SCHEMBL23047300 | 0.86 | ERBB2 (0.47) | SMN1; SMN2EGFRERBB2GAA | |
| SCHEMBL19683692 | 0.86 | ERBB2 (0.45) | SMN1; SMN2KDREGFRERBB2GAA | |
| SCHEMBL19683782 | 0.84 | EGFR (0.45) | SMN1; SMN2AURKAAURKBEGFRERBB2 | |
| SCHEMBL20878850 | 0.83 | RET (0.55) | FLT3CSF1RRETPDGFRBKIT | |
| SCHEMBL19683818 | 0.82 | RET (0.58) | FLT3CSF1RRETPDGFRBKIT | |
| SCHEMBL19683600 | 0.82 | RET (0.58) | FLT3CSF1RRETPDGFRBKIT | |
| SCHEMBL20878929 | 0.81 | RET (0.53) | FLT3CSF1RRETPDGFRBKIT | |
| SCHEMBL19683608 | 0.81 | EGFR (0.40) | FLT3SMN1; SMN2MAPTAURKAAURKB | |
| SCHEMBL19683824 | 0.80 | SRC (0.47) | RETLCKPDGFRABTKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |