SCHEMBL19683678

SCHEMBL19683678

CC(C)c1cccc(N(c2ccc(-c3ccccc3)cc2)c2ccc(-c3cc4c(o3)c(-c3ccccc3)cc3c5cc(-c6ccc(N(c7ccc(-c8ccccc8)cc7)c7cccc(C(C)(C)C)c7)cc6)oc5c(-c5ccccc5)cc43)cc2)c1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTPN5 P54829 1/20 0.31
TNKS O95271 1/20 0.30
PARP1 P09874 1/20 0.30
TNKS2 Q9H2K2 1/20 0.30
HDAC6 Q9UBN7 1/20 0.30
PARP2 Q9UGN5 1/20 0.30
RXRA P19793 2/20 0.30
RXRB P28702 2/20 0.30
RXRG P48443 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19683438 0.92 RXRA (0.34) TNKSRXRARXRB
SCHEMBL19683437 0.81 CYP1A1 (0.38) TNKSRXRARXRB
SCHEMBL19683564 0.81 CYP1A1 (0.37) RXRARXRB
SCHEMBL19265513 0.79 PTPN5 (0.33) PTPN5RXRARXRBRXRG
SCHEMBL19265425 0.76 ALDH1A1 (0.35) PTPN5RXRARXRBRXRG
SCHEMBL20987925 0.74 PTPN5 (0.35) PTPN5RXRARXRBRXRG
SCHEMBL17986894 0.74 RXRA (0.49) PTPN5RXRARXRBRXRG
SCHEMBL12922774 0.73 RXRA (0.46) PTPN5RXRARXRBRXRG
SCHEMBL2928411 0.73 RXRA (0.46) HDAC6RXRARXRBRXRG
SCHEMBL19683436 0.72 CYP26B1 (0.39) TNKSRXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017210072-A1 ELECTROACTIVE COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2017-12-07 WO disclosed