Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20878943 | 0.86 | HPGD (0.44) | HPGDLCKJAK2BTKSYK | |
| SCHEMBL20878941 | 0.85 | MKNK2 (0.37) | MKNK2MKNK1BTKPRMT1PAK1 | |
| SCHEMBL19683744 | 0.81 | CDK4 (0.42) | CCNT1CDK4CCND1CDK9CDK6 | |
| SCHEMBL23047342 | 0.79 | PRMT1 (0.41) | MKNK2JAK2PRMT1SYKEGFR | |
| SCHEMBL20878980 | 0.79 | FLT3 (0.53) | MKNK2CCNT1CDK4CDK9 | |
| SCHEMBL20878917 | 0.79 | GRM5 (0.42) | ALDH1A1HPGDJAK2BTKEGFR | |
| SCHEMBL20878931 | 0.79 | GAA (0.41) | ALDH1A1HPGDJAK2PRMT1 | |
| SCHEMBL20878945 | 0.78 | EIF2AK2 (0.42) | SYKERBB2CCNT1CDK4CCND1 | |
| SCHEMBL19683825 | 0.78 | NPC1 (0.44) | ALDH1A1SMN1; SMN2JAK2SYKEGFR | |
| SCHEMBL23047341 | 0.78 | PRMT1 (0.42) | ALDH1A1BTKPRMT1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |