Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 4/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.36 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23047341 | 0.85 | PRMT1 (0.42) | PRMT1TTBK1TTBK2EGFRAURKB | |
| SCHEMBL20878857 | 0.85 | PRMT1 (0.41) | PRMT1TTBK1TTBK2EGFRERBB2 | |
| SCHEMBL23047328 | 0.85 | EGFR (0.44) | PRMT1MEN1KMT2ATTBK1TTBK2 | |
| SCHEMBL19683621 | 0.83 | PRMT1 (0.44) | PRMT1TTBK1TTBK2EGFRERBB2 | |
| SCHEMBL19683616 | 0.82 | PRMT1 (0.43) | PRMT1TTBK1TTBK2EGFRERBB2 | |
| SCHEMBL20878945 | 0.80 | EIF2AK2 (0.42) | SYKERBB2 | |
| SCHEMBL20878934 | 0.80 | PRMT1 (0.37) | PRMT1EGFRERBB2CARM1 | |
| SCHEMBL24671954 | 0.80 | SRC (0.40) | PRMT1CARM1 | |
| SCHEMBL20878943 | 0.79 | HPGD (0.44) | RXFP1KMT2AEGFRJAK2SYK | |
| SCHEMBL23047326 | 0.79 | PRMT1 (0.39) | PRMT1TTBK1TTBK2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |