Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.42 |
| ▸ | CCND1 | P24385 | 5/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 8/20 | 0.40 |
| ▸ | FLT3 | P36888 | 8/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.40 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683825 | 0.89 | NPC1 (0.44) | CDK2FLT3CCNA1LMNA | |
| SCHEMBL20878891 | 0.89 | LMNA (0.43) | CDK4CCND1CDK6CDK9CCNT1 | |
| SCHEMBL20878945 | 0.86 | EIF2AK2 (0.42) | CDK4CCND1CDK6CDK9CCNT1 | |
| SCHEMBL19683703 | 0.81 | CAMK2D (0.40) | CDK4CCND1CDK6CDK9CCNT1 | |
| SCHEMBL20878977 | 0.80 | HRH3 (0.42) | CDK4CCND1CDK6CDK9CCNT1 | |
| SCHEMBL19683694 | 0.79 | JAK2 (0.46) | FLT3HDAC6KDRAURKAAXL | |
| SCHEMBL23047341 | 0.78 | PRMT1 (0.42) | CDK2AURKARPS6KB1AURKB | |
| SCHEMBL20878933 | 0.78 | TYK2 (0.41) | FLT3HDAC6 | |
| SCHEMBL23047342 | 0.78 | PRMT1 (0.41) | KDRAURKB | |
| SCHEMBL23047328 | 0.78 | EGFR (0.44) | FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |