Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 3/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683742 | 0.91 | KIT (0.47) | EGFRSRCMTORHDAC1ITK | |
| SCHEMBL19683865 | 0.86 | SRC (0.52) | EGFRSRCMTORHDAC1PRKDC | |
| SCHEMBL19683619 | 0.80 | SRC (0.56) | EGFRSRCMTORPRKDCPIK3CD | |
| SCHEMBL19683700 | 0.79 | FLT3 (0.48) | EGFRSRCHDAC1ITKABL1 | |
| SCHEMBL19683784 | 0.78 | FLT3 (0.68) | BTKRETLCKCSF1RPDGFRB | |
| SCHEMBL19683651 | 0.78 | SRC (0.49) | EGFRSRCMTORITKPRKDC | |
| SCHEMBL19683638 | 0.77 | SRC (0.49) | EGFRSRCMTORHDAC1PRKDC | |
| SCHEMBL20878976 | 0.76 | SRC (0.49) | EGFRSRCMTORPRKDCPIK3CD | |
| SCHEMBL23047313 | 0.75 | SRC (0.47) | EGFRSRCMTORPRKDCPIK3CD | |
| SCHEMBL20878948 | 0.74 | SRC (0.55) | EGFRSRCMTORHDAC1PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |