Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | CDK11B | P21127 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | FYN | P06241 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683785 | 0.91 | EGFR (0.46) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL19683700 | 0.88 | FLT3 (0.48) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL19683865 | 0.84 | SRC (0.52) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL20878975 | 0.82 | ADK (0.47) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL23047323 | 0.81 | BTK (0.65) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL19683743 | 0.80 | FLT3 (0.75) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL19683619 | 0.78 | SRC (0.56) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL19683651 | 0.77 | SRC (0.49) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL19683638 | 0.76 | SRC (0.49) | KITFLT3LCKBTKCSF1R | |
| SCHEMBL20878976 | 0.75 | SRC (0.49) | KITFLT3LCKBTKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |