Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.49 |
| ▸ | EGFR | P00533 | 11/20 | 0.49 |
| ▸ | ABL1 | P00519 | 10/20 | 0.43 |
| ▸ | KDR | P35968 | 10/20 | 0.43 |
| ▸ | MTOR | P42345 | 10/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.43 |
| ▸ | HCK | P08631 | 9/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.43 |
| ▸ | PRKDC | P78527 | 9/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23047313 | 0.83 | SRC (0.47) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL19683619 | 0.83 | SRC (0.56) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL19683865 | 0.81 | SRC (0.52) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL19683651 | 0.81 | SRC (0.49) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL19683638 | 0.78 | SRC (0.49) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL20878948 | 0.77 | SRC (0.55) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL23170462 | 0.76 | SRC (0.71) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL19683785 | 0.76 | EGFR (0.46) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL19683742 | 0.75 | KIT (0.47) | SRCEGFRABL1KDRMTOR | |
| SCHEMBL20878975 | 0.73 | ADK (0.47) | SRCEGFRKDM4ELCKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | Precedo Pharmaceuticals Co., Ltd. (CN) | 2019-04-10 | — | — | EP | disclosed |