Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010766 | 0.82 | HSD11B1 (0.71) | HSD11B1PDE4AHSD17B3PDE4BPDE4C | |
| SCHEMBL2012884 | 0.82 | HSD11B1 (0.71) | HSD11B1PDE4AHSD17B3PDE4BPDE4C | |
| SCHEMBL12571453 | 0.81 | HSD11B1 (0.64) | HSD11B1PDE4AHSD17B3PDE4BPDE4C | |
| SCHEMBL2010290 | 0.81 | HSD11B1 (0.66) | HSD11B1PDE4AHSD17B3PDE4BPDE4C | |
| SCHEMBL1972742 | 0.81 | HSD11B1 (0.66) | HSD11B1PDE4AHSD17B3PDE4BPDE4C | |
| SCHEMBL3401268 | 0.79 | HSD11B1 (0.61) | HSD11B1 | |
| SCHEMBL1978231 | 0.78 | HSD11B1 (0.64) | HSD11B1PDE4AHSD17B3PDE4BPDE4C | |
| SCHEMBL13182789 | 0.74 | HSD11B1 (0.64) | HSD11B1 | |
| SCHEMBL13182791 | 0.73 | HSD11B1 (0.56) | HSD11B1 | |
| SCHEMBL3239846 | 0.73 | TSHR (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008053194-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | claimed |
| EP-2086939-B8 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2011-06-22 | — | — | EP | disclosed |
| EP-2086939-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008053194-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | disclosed |