Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008004 | 0.78 | RAB9A (0.47) | TSHRFAAHALDH1A1KDM4EHPGD | |
| SCHEMBL1968395 | 0.73 | HSD11B1 (0.68) | — | |
| SCHEMBL23902890 | 0.66 | TSHR (1.00) | TSHRCNR2POLBFAAHALDH1A1 | |
| SCHEMBL28355432 | 0.66 | FAAH (0.78) | TSHRCNR2POLBFAAHALDH1A1 | |
| SCHEMBL2917775 | 0.66 | CNR2 (1.00) | TSHRCNR2POLBFAAHALDH1A1 | |
| SCHEMBL32675216 | 0.65 | KDM4E (0.64) | CNR2ALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL2979620 | 0.65 | UBE2T (0.56) | TSHRPOLBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3598305 | 0.65 | UBE2T (0.60) | TSHRPOLBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30175325 | 0.65 | UBE2T (0.56) | POLBALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL2913054 | 0.65 | FAAH (0.71) | TSHRCNR2POLBFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008053194-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | claimed |
| EP-2233480-B1 | Chemical compounds | ASTRAZENECA AB (SE) | 2013-05-29 | — | — | EP | disclosed |
| EP-2086939-B1 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2010-07-28 | — | — | EP | disclosed |