SCHEMBL19686027

SCHEMBL19686027

Cc1cn(C)c(=O)c2cc(-n3c4ccc(-c5ccccc5)cc4c4cc(-c5ccccc5)ccc43)ccc12

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 12/20 0.49
NR4A2 P43354 2/20 0.40
MAOB P27338 1/20 0.39
TNKS2 Q9H2K2 1/20 0.37
BRD9 Q9H8M2 1/20 0.37
BRD7 Q9NPI1 1/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GLA P06280 1/20 0.36
GAA P10253 1/20 0.36
GRM2 Q14416 1/20 0.36
TSPO P30536 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19685731 0.95 BRD4 (0.52) BRD4NR4A2MAOBTNKS2BRD9
SCHEMBL19685726 0.87 BRD4 (0.42) BRD4BRD9BRD7KDM4E
SCHEMBL19686043 0.87 ESR1 (0.40) BRD4NR4A2MAOBTNKS2KDM4E
SCHEMBL19686031 0.84 NR4A2 (0.46) BRD4NR4A2MAOBTNKS2ALDH1A1
SCHEMBL19685966 0.83 NR4A2 (0.43) BRD4NR4A2MAOBTNKS2ALDH1A1
SCHEMBL19686028 0.82 APP (0.35) BRD4BRD9BRD7ALDH1A1
SCHEMBL19685729 0.82 BRD4 (0.46) BRD4BRD9BRD7KDM4E
SCHEMBL19686345 0.82 ESRRA (0.43) BRD4NR4A2MAOBTNKS2KDM4E
SCHEMBL19685723 0.78 BRD4 (0.36) BRD4BRD9BRD7
SCHEMBL19685725 0.77 BRD4 (0.50) BRD4MAOBTNKS2BRD9BRD7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10714693-B2 Polycyclic compound and organic electroluminescence device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2020-07-14 US disclosed
US-20170352817-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2017-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10714693-B2 Polycyclic compound and organic electroluminescence device including the same CYC1, CCNA1, CYCS BRD4 740/4885NR4A2 2096/4885MAOB 1878/4885
US-20170352817-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME CYC1, CCNA1, CYCS BRD4 740/4885NR4A2 2096/4885MAOB 1878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.