Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24403130 | 0.78 | PGK1 (0.32) | PGK1 | |
| SCHEMBL31248906 | 0.77 | KMT2A (0.35) | PGK1MEN1KMT2AKDM4ECYP2C19 | |
| SCHEMBL2767477 | 0.77 | KMT2A (0.35) | PGK1MEN1KMT2AKDM4ECYP2C19 | |
| SCHEMBL23156371 | 0.74 | — | — | |
| SCHEMBL19049647 | 0.73 | TDP1 (0.44) | KMT2AKDM4ECYP3A4CYP2C19HIF1A | |
| SCHEMBL11985859 | 0.72 | ALDH1A1 (0.39) | MEN1KMT2AKDM4ECYP3A4CYP2C19 | |
| SCHEMBL10639171 | 0.72 | PDE10A (0.34) | MEN1KMT2AKDM4ECYP3A4CYP2C19 | |
| SCHEMBL31396216 | 0.72 | ALDH1A1 (0.39) | MEN1KMT2AKDM4ECYP3A4CYP2C19 | |
| SCHEMBL12074511 | 0.71 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL24402113 | 0.71 | MEN1 (0.33) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |