SCHEMBL19686899

SCHEMBL19686899

COC(=O)N1CC(OC)C1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.55
CHRNA4 P43681 2/20 0.55
CHRNB4 P30926 1/20 0.55
CHRNA3 P32297 1/20 0.55
TSHR P16473 1/20 0.52
PDE4B Q07343 7/20 0.35
PDE4A P27815 3/20 0.35
PDE4C Q08493 3/20 0.35
PDE4D Q08499 3/20 0.35
BRD4 O60885 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
USP2 O75604 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
HSD11B1 P28845 1/20 0.33
CYP2D6 P10635 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
CHRM2 P08172 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL791909 0.83 CHRNB2 (0.44) CHRNB2CHRNA4CHRNB4CHRNA3TSHR
SCHEMBL19686581 0.83 CHRNB2 (0.44) CHRNB2CHRNA4CHRNB4CHRNA3TSHR
SCHEMBL26793108 0.83 CHRNB2 (0.44) CHRNB2CHRNA4CHRNB4CHRNA3TSHR
SCHEMBL12791409 0.82 CHRNB2 (0.52) CHRNB2CHRNA4CHRNB4CHRNA3TSHR
SCHEMBL13335415 0.81 CHRNB2 (0.55) CHRNB2CHRNA4CHRNB4CHRNA3TSHR
SCHEMBL19687316 0.80 GAA (0.46) TSHRL3MBTL1ALDH1A1MAPTCHRM1
SCHEMBL18498089 0.80 CHRNB2 (0.72) CHRNB2CHRNA4CHRNB4CHRNA3TSHR
SCHEMBL791935 0.80 PDE4B (0.43) CHRNB2CHRNA4CHRNB4CHRNA3TSHR
SCHEMBL9989075 0.80 CHRNB2 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3TSHR
SCHEMBL19686575 0.79 CHRNB2 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017139697-A9 BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA SYNLOGIC, INC. (US) 2017-12-07 WO disclosed