Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987915 | 0.83 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNB4CHRNA3PDE4B | |
| SCHEMBL19686899 | 0.80 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL20240587 | 0.77 | JAK3 (0.40) | KMT2A | |
| SCHEMBL4277569 | 0.75 | — | — | |
| SCHEMBL19686581 | 0.73 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL9987717 | 0.73 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL791909 | 0.73 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL26793108 | 0.73 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL791935 | 0.70 | PDE4B (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL31107954 | 0.70 | PREP (0.44) | PDE4BL3MBTL1USP2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |