Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | WNT1 | P04628 | 4/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778882 | 0.91 | DYRK1A (0.39) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL17778750 | 0.86 | NR3C2 (0.38) | GSK3BPIK3CACYP2C19NR3C2RAF1 | |
| SCHEMBL17768065 | 0.86 | NR3C2 (0.38) | GSK3BPIK3CACYP2C19NR3C2RAF1 | |
| SCHEMBL17778748 | 0.86 | GSK3B (0.42) | GSK3BDYRK1AWNT1 | |
| SCHEMBL17618458 | 0.85 | TRPV1 (0.41) | GSK3BDYRK1APIK3CACYP2C19NR3C2 | |
| SCHEMBL17778744 | 0.84 | RAF1 (0.39) | NR3C2RAF1RPS6KB1 | |
| SCHEMBL17618454 | 0.84 | CYP2C19 (0.38) | PIK3CACYP2C19NR3C2RAF1RPS6KB1 | |
| SCHEMBL17778891 | 0.84 | DYRK1A (0.40) | GSK3BDYRK1APIK3CAWNT1CYP2C19 | |
| SCHEMBL17618449 | 0.83 | HPGDS (0.38) | PIK3CACYP2C19POLQRPS6KB1 | |
| SCHEMBL19736182 | 0.83 | DYRK1A (0.38) | GSK3BDYRK1APIK3CAWNT1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | GSK3B 2322/4885DYRK1A 3048/4885PIK3CA 4059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.