SCHEMBL19690462

SCHEMBL19690462

Nc1c(NC(=O)O)ccc(N2Cc3ccc(C(F)(F)F)cc3C2)c1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ DPP7 Q9UHL4 2/20 0.39
▸ KCNQ3 O43525 3/20 0.39
▸ KCNQ2 O43526 3/20 0.39
▸ NAMPT P43490 3/20 0.38
▸ MAPT P10636 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ KCNQ4 P56696 1/20 0.37
▸ KCNQ5 Q9NR82 1/20 0.37
▸ TP53 P04637 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ KIF11 P52732 1/20 0.37
▸ NOTUM Q6P988 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ KDR P35968 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19690564 0.92 NOTUM (0.41) L3MBTL1DPP7KCNQ3KCNQ2MAPT
SCHEMBL19690590 0.92 NOTUM (0.41) L3MBTL1DPP7KCNQ2MAPTALDH1A1
SCHEMBL19698452 0.87 KCNQ2 (0.56) L3MBTL1DPP7KCNQ3KCNQ2MAPT
SCHEMBL30741260 0.87 KCNQ2 (0.56) L3MBTL1DPP7KCNQ3KCNQ2MAPT
SCHEMBL19690291 0.86 TAS1R3 (0.41) DPP7KCNQ2NAMPT
SCHEMBL19698618 0.82 ALDH1A1 (0.48) L3MBTL1DPP7MAPTALDH1A1MEN1
SCHEMBL19698757 0.80 KCNQ2 (0.53) DPP7KCNQ3KCNQ2MAPTALDH1A1
SCHEMBL30741251 0.80 KCNQ2 (0.53) DPP7KCNQ3KCNQ2MAPTALDH1A1
SCHEMBL30741278 0.80 KCNQ2 (0.53) DPP7KCNQ3KCNQ2MAPTALDH1A1
SCHEMBL19698762 0.80 KCNQ2 (0.53) DPP7KCNQ3KCNQ2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives OCUTERRA THERAPEUTICS, INC. (US) 2024-01-02 — — US disclosed
US-20210309612-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES OCUTERRA THERAPEUTICS, INC. 2021-10-07 — — US disclosed
EP-3468947-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SciFluor Life Sciences, Inc. (US) 2019-04-17 — — EP disclosed
WO-2017214539-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. (US) 2017-12-14 — — WO disclosed
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. 2017-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 L3MBTL1 3042/4885DPP7 350/4885KCNQ3 3/4885
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives KCNQ2, KCNQ1, KCNQ3 L3MBTL1 3042/4885DPP7 350/4885KCNQ3 3/4885
US-20210309612-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 L3MBTL1 3042/4885DPP7 350/4885KCNQ3 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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