Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846218 | 0.83 | HDAC1 (0.53) | SMN1; SMN2TP53GPR119HDAC1HDAC6 | |
| SCHEMBL5077823 | 0.82 | NR1H2 (0.61) | HTTSMN1; SMN2LMNAHDAC1HDAC6 | |
| SCHEMBL1365222 | 0.82 | ESR2 (0.62) | HTTSMN1; SMN2LMNAHDAC1HDAC6 | |
| SCHEMBL19689700 | 0.81 | GPR119 (0.47) | SMN1; SMN2TP53GPR119DHODH | |
| SCHEMBL30527088 | 0.81 | DHODH (0.49) | GPR119DHODH | |
| SCHEMBL380505 | 0.81 | DHODH (0.49) | GPR119DHODH | |
| SCHEMBL19689701 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2LMNAGPR119DHODH | |
| SCHEMBL21724876 | 0.80 | GPR119 (0.46) | SMN1; SMN2GPR119HDAC1HDAC6DHODH | |
| SCHEMBL30681278 | 0.79 | GPR119 (0.45) | GPR119DHODH | |
| SCHEMBL30681279 | 0.78 | DHODH (0.52) | LMNATP53THRBGPR119HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468965-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER | Eli Lilly and Company (US) | 2019-04-17 | — | — | EP | disclosed |
| WO-2017213919-A1 | 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER | ELI LILLY AND COMPANY (US) | 2017-12-14 | — | — | WO | disclosed |