Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989960 | 0.82 | EPHX1 (0.70) | EPHX1MAOAANPEPSIGMAR1MMP2 | |
| SCHEMBL10005631 | 0.82 | EPHX1 (0.70) | EPHX1MAOAANPEPSIGMAR1MMP2 | |
| SCHEMBL11370850 | 0.82 | MEN1 (0.70) | MEN1KMT2ATDP1MAOACHRM2 | |
| SCHEMBL7247384 | 0.74 | MAOA (0.58) | MEN1KMT2ATDP1EPHX1MAOA | |
| SCHEMBL17710346 | 0.74 | MEN1 (0.59) | MEN1KMT2ATDP1EPHX1MAOA | |
| SCHEMBL421960 | 0.73 | EPHX1 (0.61) | MEN1KMT2ATDP1EPHX1MAOA | |
| SCHEMBL421959 | 0.73 | EPHX1 (0.61) | MEN1KMT2ATDP1EPHX1MAOA | |
| SCHEMBL17424040 | 0.72 | MAOA (0.65) | MEN1KMT2ATDP1EPHX1MAOA | |
| SCHEMBL11121889 | 0.72 | EPHX1 (0.59) | MEN1KMT2ATDP1EPHX1MAOA | |
| SCHEMBL23791770 | 0.71 | MEN1 (0.64) | MEN1KMT2ATDP1MAOACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334651-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010011821-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2010-01-28 | — | — | WO | disclosed |